AFE4460
SBASAL6 – JUNE 2022
AFE4460 Ultra-Small, Integrated AFE for Optical Bio-Sensing
1 Features
3 Description
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The AFE4460 is an analog front-end for optical biosensing applications, such as heart-rate monitoring
(HRM) and saturation of peripheral capillary oxygen
(SpO2). The device supports up to 32 switching lightemitting diodes (LEDs) and up to four photodiodes
(PDs). The AFE has two LED drivers each with 8bit current control. The device has a high dynamic
range transmit-and-receive circuitry that helps with
the sensing of very small signal levels. Up to 16
signal phase sets can be defined, each phase
set comprising a combination of LED and Ambient
phases. Low noise offset DACs at the receiver inputs
can be automatically controlled to cancel DC from
Ambient and LED light. The current from each of
the 4 PDs in each phase is converted into voltage
by TIAs, filtered, and then digitized using a common
ADC. The ADC code can be stored in a 256-sample
FIFO block. The FIFO can be read out using a SPI or
I2C interface.
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2 Applications
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Device Information
PART NUMBER
PACKAGE(1)
BODY SIZE (NOM)
AFE4460
DSBGA (36)
2.60 mm × 2.60 mm
LDO_BYP
For all available packages, see the orderable addendum at
the end of the data sheet.
RX_SUP
(1)
TX_SUP
TXN1
TXN2
TXN3
TXN4
TXN5
TXN6
TXN7
TXN8
TXP1
TXP2
TXP3
TXP4
LDO
VDD_INT
TI Gray Alternate
TX_SUP
LED_DRV2
LED_DRV1
SPI, I2C
SPI, I2C
INP1
INM1
Cf1
INM2
INP3
INM3
FIFO
Rf1
INP2
IOFFDAC_AMB1
•
IOFFDAC_LED1
•
Switch Matrix
•
Supports signal acquisition of up to 16 phase sets
Supports up to 32 LEDs, 4 PDs
Flexible allocation of LEDs, PDs in each phase
Simultaneous signal acquisition from different
sensors at different data rates
Accurate, continuous PPG monitoring:
– Low current for continuous heart-rate
monitoring on a wearable device with a typical
value: 15 μA for an LED, 15 μA for the receiver
– Peak system SNR of 115 dB
Transmitter:
– 8-Bit Programmable LED current with range
adjustable from 25 mA to 250 mA
– Mode to fire two LEDs in parallel with
independent per-phase current control
– Programmable LED on-time per-phase
– Simultaneous support of 32 LEDs for SpO2,
Multi-Wavelength HRM, and Spectroscopy
Receiver:
– Supports 4 Time-Multiplexed PD Inputs
– 4 parallel receivers (4 sets of TIA/filter)
– Individual ambient offset subtraction DAC at
each TIA Input with 8-bit per-phase control and
range adjustable up to 255-µA
– Individual LED offset subtraction DAC at each
TIA input with 9-bit per-phase control and 64µA range
– Digital ambient subtraction at ADC output
– Noise filtering with programmable bandwidth
– Transimpedance gain: 3.7 kΩ to 1 MΩ
Supports external clock or internal oscillator
Option to acquire data synchronized with a system
clock
Automatic cancellation of DC from Ambient, LED
FIFO with 256-sample depth
SPI™ interface/ I2C interface
2.6-mm × 2.6-mm DSBGA, 0.4-mm Pitch
Supplies: Rx:1.7 - 1.9 V (LDO Bypass); 1.9 - 3.6 V
(LDO Enabled), Tx: 3-5.5 V, IO: 1.7-RX_SUP
+
TIA1
TI Gray Alternate
–
Noise
Reduction
Filter
M
U
X
ADC
Processing,
Decimation
Filters
8 MHz
Oscillator
Timing
Engine
Rf1
ADC_RDY
INP4
Cf1
INM4
AACM
4 PPG RX Channels
GPIO
256 kHz
Oscillator
CLK
Optical Heart-Rate Monitoring (HRM) for
wearables, hearables
Heart-Rate Variability (HRV)
Pulse Oximetry (SpO2) measurements
Optical Spectroscopy
An IMPORTANT NOTICE at the end of this data sheet addresses availability, warranty, changes, use in safety-critical applications,
intellectual property matters and other important disclaimers. PRODUCTION DATA.
AFE4460
www.ti.com
SBASAL6 – JUNE 2022
Table of Contents
1 Features............................................................................1
2 Applications..................................................................... 1
3 Description.......................................................................1
4 Revision History.............................................................. 2
5 Device and Documentation Support..............................3
5.1 Documentation Support.............................................. 3
5.2 Receiving Notification of Documentation Updates......3
5.3 Support Resources..................................................... 3
5.4 Trademarks................................................................. 3
5.5 Electrostatic Discharge Caution..................................3
5.6 Glossary......................................................................3
6 Mechanical, Packaging, and Orderable Information.... 3
4 Revision History
NOTE: Page numbers for previous revisions may differ from page numbers in the current version.
2
DATE
REVISION
NOTES
June 2022
*
Initial Release
Submit Document Feedback
Copyright © 2022 Texas Instruments Incorporated
Product Folder Links: AFE4460
AFE4460
www.ti.com
SBASAL6 – JUNE 2022
5 Device and Documentation Support
TI offers an extensive line of development tools. Tools and software to evaluate the performance of the device,
generate code, and develop solutions are listed below.
5.1 Documentation Support
5.1.1 Related Documentation
5.2 Receiving Notification of Documentation Updates
To receive notification of documentation updates, navigate to the device product folder on ti.com. Click on
Subscribe to updates to register and receive a weekly digest of any product information that has changed. For
change details, review the revision history included in any revised document.
5.3 Support Resources
TI E2E™ support forums are an engineer's go-to source for fast, verified answers and design help — straight
from the experts. Search existing answers or ask your own question to get the quick design help you need.
Linked content is provided "AS IS" by the respective contributors. They do not constitute TI specifications and do
not necessarily reflect TI's views; see TI's Terms of Use.
5.4 Trademarks
TI E2E™ is a trademark of Texas Instruments.
All trademarks are the property of their respective owners.
5.5 Electrostatic Discharge Caution
This integrated circuit can be damaged by ESD. Texas Instruments recommends that all integrated circuits be handled
with appropriate precautions. Failure to observe proper handling and installation procedures can cause damage.
ESD damage can range from subtle performance degradation to complete device failure. Precision integrated circuits may
be more susceptible to damage because very small parametric changes could cause the device not to meet its published
specifications.
5.6 Glossary
TI Glossary
This glossary lists and explains terms, acronyms, and definitions.
6 Mechanical, Packaging, and Orderable Information
The following pages include mechanical, packaging, and orderable information. This information is the most
current data available for the designated devices. This data is subject to change without notice and revision of
this document. For browser-based versions of this data sheet, refer to the left-hand navigation.
Submit Document Feedback
Copyright © 2022 Texas Instruments Incorporated
Product Folder Links: AFE4460
3
PACKAGE OPTION ADDENDUM
www.ti.com
9-Dec-2022
PACKAGING INFORMATION
Orderable Device
Status
(1)
Package Type Package Pins Package
Drawing
Qty
Eco Plan
(2)
Lead finish/
Ball material
MSL Peak Temp
Op Temp (°C)
Device Marking
(3)
Samples
(4/5)
(6)
AFE4460YBGR
ACTIVE
DSBGA
YBG
36
3000
RoHS & Green
SAC396
Level-1-260C-UNLIM
-40 to 85
AFE4460
Samples
AFE4460YBGT
ACTIVE
DSBGA
YBG
36
250
RoHS & Green
SAC396
Level-1-260C-UNLIM
-40 to 85
AFE4460
Samples
(1)
The marketing status values are defined as follows:
ACTIVE: Product device recommended for new designs.
LIFEBUY: TI has announced that the device will be discontinued, and a lifetime-buy period is in effect.
NRND: Not recommended for new designs. Device is in production to support existing customers, but TI does not recommend using this part in a new design.
PREVIEW: Device has been announced but is not in production. Samples may or may not be available.
OBSOLETE: TI has discontinued the production of the device.
(2)
RoHS: TI defines "RoHS" to mean semiconductor products that are compliant with the current EU RoHS requirements for all 10 RoHS substances, including the requirement that RoHS substance
do not exceed 0.1% by weight in homogeneous materials. Where designed to be soldered at high temperatures, "RoHS" products are suitable for use in specified lead-free processes. TI may
reference these types of products as "Pb-Free".
RoHS Exempt: TI defines "RoHS Exempt" to mean products that contain lead but are compliant with EU RoHS pursuant to a specific EU RoHS exemption.
Green: TI defines "Green" to mean the content of Chlorine (Cl) and Bromine (Br) based flame retardants meet JS709B low halogen requirements of
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